Page 67 - CIBERDEM-2015-eng

Research groups
Most relevant scientific articles
GORE AC, CHAPPELL VA, FENTON SE, FLAWS JA, NADAL A, PRINS GS ET AL. EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocrine reviews. 2015;36(6):E1-E150.
VIEIRA E., MERINO B., QUESADA I.. Role of the clock gene Rev-erbα in metabolism and in the endocrine pancreas. Diabetes, Obesity and Metabolism. 2015;17(S1):106-114.
ALONSO-MAGDALENA P., GARCíA-AREVALO M., QUESADA I., NADAL A.. Bisphenol-A treatment during pregnancy in mice: A new window of susceptibility for the develop- ment of diabetes in mothers later in life. Endocrinology. 2015;156(5):1659-1670.
Highlights
During 2015 we have shown that, at the intial steps of obesity induced by a high-fat diet, the pancreatic alpha cell undergoes several functional and struc- tural changes, leading to hipoglucagonemia which could have a positive influence on the adaptations of the pancreas during obesity to maintain glucose homeostasis and prevent / delay the potential onset of diabetes.
MERINO B., ALONSO-MAGDALENA P., LLUESMA M., NECO P., GONZáLEZ A., MARROQUI L. ET AL. Pancreatic alpha-cells from female mice undergo morphofunctional changes during compensatory adaptations of the endocrine pan- creas to diet-induced obesity. Scientific Reports. 2015;5:-.
IRLES E., NECO P., LLUESMA M., VILLAR-PAZOS S., SANTOS-SIL- VA J.C., VETTORAZZI J.F. ET AL. Enhanced glucose-induced intracellular signaling promotes insulin hypersecretion: Pancreatic beta-cell functional adaptations in a model of genetic obesity and prediabetes. Molecular and Cellular Endocrinology. 2015;404:46-55.
In a second line of research, we have shown that exposure to endocrine disruptors during pregnancy increases the susceptibility of the mother to obesity and diabetes throughout her life. Within this line, we have participated in the preparation of the second official document of the Endocrine Society USA on Endocrine Disruptors (Gore et al, Endocrine Reviews 2015).
Institution: Universidad Miguel Hernández · Contact: Instituto de Bioingeniería · Edificio Vinalopo. Avda. De la Universidad S/N. 03202 Elche · Tel.: 96 522 20 02 · E.mail: [email protected]
Website: http://diabetes.umh.es
CIBERDEM I Annual report 2015 I 67