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Most relevant scientific articles
• Amigó N, Mallol R, Heras M, Martínez-Hervás S, Blanco-Vaca F, Escolà-Gil JC et al. Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes.Scientific reports. 2016;6:19249.
• Rafols P., Vilalta D., Brezmes J., Canellas N., del Castillo E., Yanes O. et al. Signal preprocessing, multivariate analysis and software tools for MA(LDI)-TOF mass spectrometry imaging for biological applications. Mass Spectrometry Reviews. 2016.
• Vinaixa M., Schymanski E.L., Neumann S., Navarro M., Salek R.M., Yanes O. Mass spectral databases for LC/MS- and GC/MS-based metabolomics: State of the field and future prospects. TrAC - Trends in Analytical Chemistry. 2016;78:23-35.
• Capellades J., Navarro M., Samino S., García-Ramírez M., Hernández C., Simo R. et al. geoRge: A Computational Tool to Detect the Presence of Stable Isotope Labeling in LC/MS-Based Untargeted Metabolomics. Analytical Chemistry. 2016;88(1):621-628.
• Domingo-Almenara X., Brezmes J., Vinaixa M., Samino S., Ramírez N., Ramon-Krauel M. et al. ERah:
A Computational Tool Integrating Spectral Deconvolution and Alignment with Quantification and Identification of Metabolites in GC/MS-Based Metabolomics. Analytical Chemistry. 2016;88(19):9821-9829.
Highlights
COLLABORATIOnS
• Seven collaborations with groups from Ciberdem: Dr. Guinovart, Dr. Simó, Dr. Masana, Dr. Mauricio, Dr. Vendrell, Dra. Burks, Dra. Martínez Valverde; and 4 with other CIBER’s: Dr. Azpiroz (CIBEREHD), Dr. Salas Salvadó (CIBEROBN), Dr. Vila Bover (CIBERNED), Dra. Ardanuy (CIBEReS). Other collaborations with national and international groups: Dr. Gomis (IRB), Dr. Stracker (IRB), Dr. Quintela (CNIO), Dr. Salek (EBI- EMBL), Dr. Neumann (Leibniz Institute of Plant Biochemistry), Dra. Schymanski (Swiss Federal Institute of Aquatic Science and Technology), Dr. Jourdan (INRA), Dr. Shabaz Mohammed (University of Oxford), Dr. Thomas (IDIBELL, Barcelona), Dr. Buschbeck (IMPPC), Dr. Beato (CRG), Dr. Cantó (Nestlé Institute
of Health Sciences), Dr. Jimenez Chillaron (Hospital Sant Joan de Deu), Dr. Guimerà (URV-ICREA), Dra. Colomina (URV, Tarragona), Dr. Loda (Dana-Farber Cancer Institute), Dra. Martins-Green (University of California), Dra. Mora (Brigham and Women’s Hospital), Dr. Davidson (University of Ulster), Dr. Alexandrov (EMBL).
RELEVAnT PROJECTS
• BFU2014-57466-P. Rethinking cellular metabolism through identification of unpredicted metabolites and biochemical transformations using a novel metabolomic approach.
H2020-MSCA-ITN-2015. Chromatin–metabolism interactions as targets for healthy living. TEC2012-31074: Development of nanostructured surfaces and processing algorithms for obtaining and
treatment of metabolic images measured by laser desorption ionization mass spectrometry (LDI-MS).
RELEVAnT RESULTS ACHIEVED
• Development of a method for profiling of glycoproteins in blood measured by 1HNMR.
• Identification of metabolic markers in the vitreous humor of patients with diabetic retinopathy.
• Development of algorithms for fluxomics experiments based on LC-MS and NMR.
• Creation and validation of a new algorithm for the identification of unknown metabolites by GC-MS.
• Obtaining and processing metabolic images of mass spectrometry by metal nanoparticles (NP-LDI-MSI).
DEM
research groups 51