Page 77 - CIBERDEM-2015-eng

Research groups
Most relevant scientific articles
RUIZ-DEDIEGO I., MELLSTROM B., VALLEJO M., NARANJO J.R., MORATALLA R.. Activation of DREAM (Downstream Regu- latory Element Antagonistic Modulator), a calcium-bind- ing protein, reduces L-DOPA-induced dyskinesias in mice. Biological Psychiatry. 2015;77(2):95-105.
Highlights
During 2015 we characterized in detail a molecular mechanism by which glucagon gene expression is suppressed in response to increases in blood glu- cose levels, thereby contributing to the maintenance of glucose homeostasis. The relevance of this find- ing lies in the recent recognition of the existence of abnormally high levels of glucagon in the blood of di- abetic patients, even in conditions of hyperglycemia. Therefore a defect in these mechanisms, in which transcription factors Pax6 and Alx3 are involved, could contribute significantly to the pathogenesis of this disease (Mirasierra and Vallejo, Diabetologia, DOI 10.1007 / s00125-015-3849-4)
Our group oversees the management of the Indirect Calorimetry and Energy Metabolism Unit (UCIME), which provides the use of a Phenomaster system (TSE Systems) as a technology platform provided by CIBERDEM for evaluating energy metabolism in rodents.
Project granted: Transcriptional control of meta- bolic homeostasis at a multiorganic level by the homeodomain transcription factor Alx3. Ministerio de Economía y Competitividad, BFU2014-52149-R. Duration, 2015-2017.
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas
Contact: Instituto de Investigaciones Biomédicas Alberto Sols · C/ Arturo Duperier 4. 28029 Madrid Tel.: 91 585 44 80 · E.mail: [email protected]
Website: http://www.iib.uam.es/portal/web/guest/investigacion/grupos
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