Page 79 - CIBERDEM-2015-eng

Research groups
Most relevant scientific articles
SALVADO L., PALOMER X., BARROSO E., VAZQUEZ-CARRE- RA M.. Targeting endoplasmic reticulum stress in insulin resistance. Trends in Endocrinology and Metabolism. 2015;26(8):438-448.
PALOMER X., CAPDEVILA-BUSQUETS E., BOTTERI G., DA- VIDSON M.M., RODRíGUEZ C., MARTíNEZ-GONZáLEZ J. ET AL. MiR-146a targets Fos expression in human car- diac cells. DMM Disease Models and Mechanisms. 2015;8(9):1081-1091.
CHEHAIBI K, CEDó L, METSO J, PALOMER X, SANTOS D, QUE- SADA H ET AL. PPAR-β/δ activation promotes phospholipid transfer protein expression.Biochemical pharmacology. 2015;94(2):101-8.
PETROV D., PEDROS I., ARTIACH G., SUREDA F.X., BARROSO E., PALLAS M. ET AL. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeo- stasis deficiences contribute to Alzheimer disease pathol- ogy in rodents. Biochimica et Biophysica Acta - Molecular
BARROSO E., RODRíGUEZ-RODRíGUEZ R., CHACON M.R., MAYMO-MASIP E., FERRER L., SALVADO L. ET AL. PPARβ/δ ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation. Biochimi- ca et Biophysica Acta - Molecular Basis of Disease. 2015;1852(5):1049-1058.
Highlights
RESULTS:
• Adipose tissue macrophage infiltration and in- flammation as well as glucose intolerance are aggravated in fructose-fed PPARb/d-null mice via nuclear factor E2-related factor 2 (Nrf2).
• miR-146a might be a new and promising thera- peutic tool for treating cardiac disorders associ- ated with enhanced inflammation in the heart.
• PPAR-ß/d activation may modulate phospholipid transfer protein-mediated preß-HDL formation and macrophage cholesterol efflux.
DOCTORAL THESIS:
• Title: Adamentane-like scaffolds for a wide range of therapeutic targets. PhD candidate: Elena Val- verde Murillo. Supervisors: Santiago Vázquez Cruz and Manuel Vázquez Carrera.
• Title: Curta administração de GW501516 mel- hora o estado inflamatório do tecido adiposo branco, o dano hepático e a inflamação renal de camundongos alimentados com dieta rica em frutose. PhD candidate: D’Angelo Carlo Magliano. Directores: Márcia Barbosa Águila, Mandarim de Lacerda and Manuel Vázquez-Carrera.
Basis of Disease. 2015;1852(9):1687-1699.
RESEARCH PROJECTS:
• Title: Cardiomiopatía diabética: a la búsqueda de una nueva diana terapéutica. La Marató de TV3. Ref. 201542.
• Title: Medicamentos para trastornos inflamatori- os y cardiovasculares. CaixaImpulse.
PATENT.
Inventors: Santiago Vázquez Cruz, Elena Valverde Murillo and Manuel Vázquez Carrera. Title: Analogs of adamantylureas as soluble epoxide hydrolase in- hibitors. Number: P3392EP00.
Institution: Universitat de Barcelona · Contact: Facultad de Farmacia.
Diagonal, 645. 08028 Barcelona · Tel.: 93 402 45 31 · E.mail: [email protected] Website: http://www.ciberdem.org/grupo.php?id=29
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