Page 65 - CIBERDEM2016-ENG

• Study of the polarization of microglia (M1/M2) in diabetic retinopathy (DR): targeting microglia polarization as a therapeutic approach at the early stages of DR.
• Physiological role of proinsulin and the consequences of inappropriately high levels during cardiogénesis.
• Involvement of Tyrosine Hydroxilase in the metabolic adaptations to diet and temperature stressors.
Most relevant scientific articles
• Arroba A.I., Alcalde-Estèvez E., García-Ramírez M., Cazzoni D., de la Villa P., Sánchez-Fernández E.M. et al. Modulation of microglia polarization dynamics during diabetic retinopathy in db/db mice. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2016;1862(9):1663-1674.
• García-Casarrubios E., de Moura C., Arroba A.I., Pescador N., Calderón-Domínguez M., García L. et
al. Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(12):1929-1941.
• Hernández C, Bogdanov P, Corraliza L, García-Ramírez M, Solà-Adell C, Arranz JA et al. Topical Administration of gLP-1 Receptor Agonists Prevents Retinal neurodegeneration in Experimental Diabetes. Diabetes. 2016;65(1):172-87.
• Isiegas C., Marinich-Madzarevich J.A., Marchena M., Ruiz J.M., Cano M.J., De La Villa P. et al. Intravitreal injection of proinsulin-loaded microspheres delays photoreceptor cell death and vision loss in the rd10 mouse model of retinitis pigmentosa. Investigative Ophthalmology and Visual Science. 2016;57(8):3610- 3618.
• Arroba A.I., de la Rosa L.R., Murillo-Cuesta S., Vaquero-Villanueva L., Hurle J.M., Varela-Nieto I. et al. Autophagy resolves early retinal inflammation in Igf1-deficient mice. DMM Disease Models and Mechanisms. 2016;9(9):965-974.
Highlights
SCIEnTIFIC PROJECTS
• “Identification of novel modulators of chronic inflammation in prevalent diseases: unveiling divergent mechanisms of disease”. INFLAMES. PIE14/00045, Proyecto Integrado de Excelencia, Convocatoria 2014 de la Acción Estratégica en Salud 2013-16, ISCIII. Coordinator: Antonio Zorzano Olarte Principal Investigator of WP3: Ángela María Martínez Valverde. Total funding: 679.800 euros. From 01/01/2015 to 12/31/2017.
• “Inflammation associated with chronic metabolic damage in Type 2 diabetes and its complications. SAF 2015-65.267 RETOS (2016-2018) (MINECO/FEDER). Principal Investigator: Ángela María Martínez Valverde. Total funding: 180.000 euros and a predoctoral contract FPI. From 01/01/2016 to 12/31/2018.
• “Estrategias neuroprotectoras para la Retinosis Pigmentaria basadas en la modulación de la muerte celular y la inflamación”. SAF2013-41059-R. Principal Investigators: Flora de Pablo y Enrique J. de la Rosa. Total funding: 295.999 euros. From 01/01/2014-to 30/09/2017.
• RESEARCH NETWORK IN NRF2 AS A NODE OF PATHOGENOSOME. SAF2015-71304-REDT (2016-2017) MInECO. Coordinator: Antonio Cuadro Pastor. Principal Investigator: Ángela Martínez Valverde. Cuantía TOTAL de la subvención: 35.000 euros. Fecha inicio/finalización: desde 01/01/2015 hasta 31/12/2017.
AWARDS
• AWARD CONSEJO DE COLEGIOS FARMACÉUTICOS. ROYAL NATIONAL ACADEMY OF PHARMACYREAL ACADEMIA NACIONAL DE FARMACIA (Scientific award 2016). Ángela Martínez Valverde and Ana I Arroba Espinosa. “Targeting microglia polarization: a new therapeutic approach in Diabetic Retinopathy”.
DEM
research groups 65