Page 63 - CIBERDEM2016-ENG

Most relevant scientific articles
• Tapia-Limonchi R., Cahuana G.M., Caballano-Infantes E., Salguero-Aranda C., Beltran-Povea A., Hitos A.B. et al. Nitric Oxide Prevents Mouse Embryonic Stem Cell Differentiation Through Regulation of gene Expression, Cell Signaling, and Control of Cell Proliferation. Journal of Cellular Biochemistry. 2016.
• Soria B., Montanya E., Martín F., Hmadcha A. A role for the host in the roadmap to diabetes stem cell therapy. Diabetes. 2016;65(5):1155-1157.
• Munoz-Bravo J.L., Flores- Martínez A., Herrero-Martin G., Puri S., Taketo M.M., Rojas A. et al. Loss of pancreas upon activated Wnt signaling is concomitant with emergence of gastrointestinal identity. PLoS ONE. 2016;11(10).
• Jurado-Ruiz E., Varela L.M., Luque A., Berna G., Cahuana G., Martínez-Force E. et al. An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat “Western-type” diet in mice. Molecular nutrition and Food Research. 2016.
• Fontan-Lozano A., Capilla-González V., Aguilera Y., Mellado N., Carrion A.M., Soria B. et al. Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency. The role of DREAM in the maintenance of hESCs.Stem Cell Research. 2016;16(3):568-578.
Highlights
A new differentiation protocol to obtain insulin secreting cells from mouse embryonic stem cells has been developed. In the new protocol, the biphasic pattern of Pdx1 expression has been induced by using nitric oxide and an inhibitor of p330.
The clinical assay ((AdMSC Diabetes; EudraCT: 2008-001837-88; ClinicalTrial.gov Identifier: NCT01257776) has been finished. This assay has demonstrated the positive effects of an intra-arterial injection of mesenchymal stem cells for diabetic food. The patients avoided the need for amputation, improved their vasculogenesis and their Rutheford Becker classification. Finally, the patients had a significant reduction of their ulcers and pain.
The loss of GAT6 in the function of beta cells induces a glucose intolerance after the fifth month of ages.
It has been proven that GAT6 is key to insulin synthesis, the regulation of specific beta cell transcription factors and for the regulation of the genes involved insulin release.
In a mouse model of high-fat diet type 2 diabetes, it has been shown that the modification of the fats profile for monounsaturated rich-phenolics fats (coming from extra virgin olive oil) improve glucose homeostasis. The mechanisms for this improvement are: i) a decrease of insulin resistance; ii) a better stimulus-secretion coupling and iii) a decrease of beta cell apoptosis, as well as, an increase in beta cell mass.
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