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leaD researcher
Martínez Valverde, Ángela María
Agencia Estatal Consejo Superior de Investigaciones Científicas
Instituto de Investigaciones Biomédicas Alberto Sols
C/ Arturo Duperier 4
28029 Madrid
(+34) 91 585 44 97 [email protected] group Website
gROUP MEMBERS
Staff members: Abancéns Izcue, María | Ruiz Cañas, Laura | Valdecantos Jiménez De Andrade, María Pilar | Vázquez Pérez, Patricia
Associated members: Ahmed, Maysha | De Pablo Davila, Flora | Hernández Sánchez, Catalina | Rada Llano, Patricia | Rubio Caballero, Carmen | Santamaría Perez, Beatriz | Villar Lorenzo, Andrea
Main lines of research
• Study of the molecular mechanisms associated to the progression of non-alcoholic fatty liver disease (NAFLD):
- Dual role of the protein tyrosine phosphatase 1B (PTP1B) in NAFLD: from intestinal inflammation to hepatic fibrosis.
- Cross-talk between different liver cells (hepatocytes, Kuffer cells, stellate cells) in the context of NAFLD progression: molecular mechanisms involved.
- Differential effects of single and dual agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in the treatment of NAFLD at stages of non-alcoholic steatohepatitis (NASH). - Role of insulin receptor substrate 2 (IRS2) in the epithelial-mesenchymal transition (EMT) in hepatic cells in insulin resistant states.
• Differential therapeutic effects of single and dual agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in the treatment of insulin resistance associated to obesity: effects of these drugs in the brown adipose tissue.
• Effect of low grade chronic inflammation on insulin and catecholamine sensitivity in brown adipocytes: molecular mechanisms involved and therapeutic strategies.
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