Page 55 - CIBERDEM2016-ENG

Most relevant scientific articles
• Escobar-Morreale H.F., Roldán-Martín M.B. Type 1 diabetes and polycystic ovary syndrome: Systematic review and meta-analysis. Diabetes Care. 2016;39(4):639-648.
• Botella-Carretero J.I., Lafuente C., Montes-Nieto R., Balsa J., Vega-Pinero B., Garcia-Moreno F. et al. Serum Bioavailable Vitamin D Concentrations and Bone Mineral Density in Women After Obesity Surgery. Obesity Surgery. 2016;26(11):2732-2737.
• Luque-Ramírez M., Escobar-Morreale H.F. Adrenal hyperandrogenism and polycystic ovary syndrome. Current Pharmaceutical Design. 2016;22(36):5588-5602.
• Escobar-Morreale HF, Martínez-García MÁ, Montes-Nieto R, Fernández-Durán E, Temprano-Carazo S, Luque-Ramírez M. Effects of glucose ingestion on circulating inflammatory mediators: Influence of sex and weight excess. Clinical nutrition (Edinburgh, Scotland). 2016.
Highlights
During 2016, the group has focused on the execution of the following projects “Effects on cardiovascular risk factors of decreasing iron tissue deposits in women with polycystic ovary syndrome: a proof-of-concept study” (PI14/00649) and “Infuence of sex and sex hormones on adipose tissue dysfunction and chronic metabolic disorders of complex etiology (SEXMETAB)” (PI15/01686). The SEXMETAB study, which includes animal and human experiments, will allow us to address the novel issue of gonadal dysfunction in men and its relation to metabolic dysfunction. Moreover, our previous project on the study of the hormonal, metabolic, inflammatory and oxidative stress response to dietary macronutrients and the influence of sex steroids is in its final phase of publication and dissemination (PI11/0357).
Also, in 2016, the group has received founding from an Excellence Integrated Project “Influence of sex and sex hormones on human chronic disorders of complex etiology -SEXCOMPLEX-” (PIE16/00050), which aim is to study the differences between women and men in several complex chronic diseases. The objective will focus on the mechanisms involved in the influence of sex and sexual steroids on the pathophysiology and clinical presentation of the proposed diseases. The group will coordinate the project in cooperation with six other groups of Instituto Ramón y Cajal de Investigación Sanitaria, three of them belong to other CIBERs.
In the field of training, our group got a post-doctoral contract Río Hortega Specialized Sanitary
Training for the study of the prevalence of mutations in the InSR and LMnA genes in functional ovarian hyperandrogenism with insulin resistance.
Regarding scientific publications, the meta-analysis on the frequent association of polycystic ovarian syndrome and its signs and symptoms with type 1 diabetes, published in the journal Diabetes Care,
should be highlighted. This study points to the importance of diagnosing and treating polycystic ovarian syndrome in women with type 1 diabetes as well as the inclusion of screening in clinical guidelines for the management of type 1 diabetes.
DEM
research groups 55