Page 47 - CIBERDEM2016-ENG

Most relevant scientific articles
• Martínez-Larrad M.T., Corbaton-Anchuelo A., Fernández-Pérez C., Lazcano-Redondo Y., Escobar- Jiménez F., Serrano-Ríos M. Metabolic syndrome, glucose tolerance categories and the cardiovascular risk in Spanish population. Diabetes Research and Clinical Practice. 2016;114:23-31.
• Martínez Larrad M.T., Corbaton Anchuelo A., Fernández-Pérez C., Pérez Barba M., Lazcano Redondo Y., Serrano Ríos M. et al. Obesity and cardiovascular risk: Variations in visfatin gene can modify the obesity associated cardiovascular risk. Results from the Segovia population based-study. Spain. PLoS ONE. 2016;11(5).
• Brugnara L., Murillo S., Novials A., Rojo-Martínez G., Soriguer F., Goday A. et al. Low physical activity and its association with diabetes and other cardiovascular risk factors: A nationwide, population-based study. PLoS ONE. 2016;11(8).
• García-Casarrubios E., de Moura C., Arroba A.I., Pescador N., Calderón-Domínguez M., García L. et al. Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(12):1929- 1941.
• Walford G.A., Gustafsson S., Rybin D., Stancakova A., Chen H., Liu C.-T. et al. genome-wide association study of the modified stumvoll insulin sensitivity index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci. Diabetes. 2016;65(10):3200-3211.
Highlights
• Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a gWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed a gWAS
of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin- Related Traits Consortium.
We identified two novel loci and replicated known variants associated with insulin sensitivity. Further
studies are needed to clarify the causal variant and function at the BCL2 and FAM19A2 loci.
• Our aim was to investigate if genetic variations in the visfatin gene (SNPs rs7789066/ rs11977021/
rs4730153) could modify the cardiovascular-risk (CV-risk) despite the metabolic phenotype (obesity and glucose tolerance). In addition, we investigated the relationship between insulin sensitivity and variations in visfatin gene. This is the first study which concludes that the genotype AA of the rs4730153 SnP appear to protect against CV-risk in obese and non-obese individuals, estimated by Framingham and SCORE charts. Our results confirm that the different polymorphisms in the visfatin gene might be influencing the glucose homeostasis in obese individuals.
• We examined the prevalence of metabolic syndrome (MetS), glucose tolerance categories and risk factors of cardiovascular-disease (CVD) in the general Spanish population. Prevalence of MetS has not changed in the past decade in Spanish females, but has slightly increased in males. We found that subjects with IgT showed a higher risk of CVD than IFg and IFg/IgT according to the Framingham and SCORE. MetS increased the CVD-risk previously estimated by Framingham and SCORE.
• [email protected] Study. [email protected] II is ongoing.
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