Page 35 - CIBERDEM2016-ENG

• Role of omega-3 fatty acid derivatives as deactivators of monocyte/macrophage activation via their antagonistic effects on inflammasome activation or other mechanisms of pathophysiological relevance.
Most relevant scientific articles
• Sala-Vila A., Navarro-Lérida I., Sánchez-Álvarez M., Bosch M., Calvo C., López J.A. et al. Interplay between hepatic mitochondria-Associated membranes, lipid metabolism and caveolin-1 in mice. Scientific Reports. 2016;6.
• Pena L., Meana C., Astudillo A.M., Lorden G., Valdearcos M., Sato H. et al. Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(9):1083-1095.
• Guijas C., Meana C., Astudillo A.M., Balboa M.A., Balsinde J. Foamy Monocytes Are Enriched in cis-7- Hexadecenoic Fatty Acid (16:1n-9), a Possible Biomarker for Early Detection of Cardiovascular Disease. Cell Chemical Biology. 2016;23(6):689-699.
• Lordén G, Sanjuán-García I, de Pablo N, Meana C, Álvarez-Miguel I, Pérez-García MT et al. Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. The Journal of experimental medicine. 2016.
Highlights
gRAnTS ACTIVE In 2016
• “Lipid Pathways Regulating the Inflammasome: Role of Omega-3 Fatty Acids and Lipin-2”. Ministry of
Economy and Competitiveness (SAF2013-48201-R).
• “Positional Isomers and Oxygenated Derivatives of Palmitoleic Acid as New Mediators of Inflammation”.
Autonomous Government of Castile and Leon, Education Department ((JCYL CSI073U16).
RESEARCH COnTRACTS WITH PRIVATE COMPAnIES
• FIV Recoletos, “Study of the role of the eicosanoids in implantation and in gestational diabetes”.
• Mozo-Grau, “Fluids that promote or increase the osseointegration of implants in diabetic individuals”.
MOST RELEVAnT RESULTS
• Discovery that lipin-2, an enzyme of triglyceride and phospholipid metabolism, plays a key role in regulating
interleukin-1ß production in macrophages through its effects on NLRP3 inflammasome assembly. These findings provide a molecular explanation for Majeed Syndrome, an autoinflammatory disease caused by inactivating mutations of the gene encoding for lipin-2.
• Description of the presence of an unusual isomer of palmitoleic acid, cis-7-hexadecenoic acid, in human peripheral blood monocytes. This fatty acid shows a strong anti-inflammatory character in vitro and in vivo, and its levels appear to be regulated by the activation state of the cells, which could be useful as a biomarker of ‘foamy monocyes’ for the early detection of cardiovascular disease.
TRAInIng
• PhD thesis: “Regulation of lipid droplet formation by arachidonic acid in human monocytes. Relevance of
the fatty acid 16:1n-9”, Carlos guijas Maté, University of Valladolid.
• PhD thesis: “Lipin-2 regulation of NLRP3 inflammasome activation in macrophages”, Gema Lordén Losada,
University of Valladolid.
• MSc thesis: “Levels of docosahexaenoic acid (22:6n-3) in mouse peritoneal macrophages”, Laura Pereira de
Blas, University of Valladolid.
DEM
research groups 35