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leaD researcher
Benito De las Heras, Manuel Román
Universidad Complutense de madrid
Facultad de Farmacia Ciudad Universitaria, S/n 28040 Madrid
(+34) 91 394 17 77 [email protected] group Website
gROUP MEMBERS
Staff members: Fernández López, Silvia | García Gómez, Gema | González Trujillos, Elena
Associated members: Bartolomé Herrainz, Alberto | Díaz-Castroverde Vicario, Sabela | Escribano Illanes, Óscar | Gómez Hernández, Almudena | Guillen Viejo, Carlos | Pedromo Loaiza, Liliana | Viana Huete, Vanesa
Main lines of research
• Compensatory mechanisms to hepatic insulin resistance: Progression to type 2 diabetes and the crossroad of autophagy and apoptosis in the pancreatic beta cells.
A.- The role of the liver-pancreas endocrine axis in triggering beta-cell hyperplasia. The insulin receptor and its isoforms as gene therapy of the diabetic hyperglycemia.
B.- The role of autophagy, mitophagy and ER stress in the regulation of beta-cell pancreatic mass and beta-cell failure.
C.- The role of human amylin as a link between the pancreatic beta cell failure and neurodegeneration.
• Adipose organ inflammatory disease and the cardiovascular damage:
D.- BATIRKO/apoE -/- DKO mice: The role of the compensatory mechanisms of insulin resistance in the aggravation/attenuation of inflammation, oxidative stress and vascular lesion in the aorta.
• Brown fat function/dysfunction and adipose organ inflammatory disease.
E.1.- new mouse models to study energy imbalance and body weight regulation: Brown adipose tissue- specific knockout of IGFIR and IGFIR/IR DKO.
E.2.- New mouse models of browning: Brown adipose tissue-specific knockout of p85 alpha/PI 3 kinase. E.3.- Role of IR and IGFIR in the mitochondrial dynamics in vitro and in vivo.
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