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Most relevant scientific articles
• Martinez-Hervas S., Artero A., Martinez-Ibanez J., Tormos M.C., González-Navarro H., Priego A. et al. Increased thioredoxin levels are related to insulin resistance in familial combined hyperlipidaemia. European Journal of Clinical Investigation. 2016;46(7):636-642.
• Martinez-Hervas S., Navarro I., Real J.T., Artero A., Peiro M., González-Navarro H. et al. Unsaturated oral fat load test improves glycemia, insulinemia and oxidative stress status in nondiabetic subjects with abdominal obesity. PLoS ONE. 2016;11(8).
• Marrachelli V.G., Rentero P., Mansego M.L., Morales J.M., Galan I., Pardo-Tendero M. et al. Genomic and metabolomic profile associated to clustering of cardio-metabolic risk factors. PLoS ONE. 2016;11(9).
• Andres-Blasco I., Vinue A., Herrero-Cervera A., Martinez-Hervas S., Nunez L., Piqueras L. et al. Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIgHT/ lymphotoxin β-receptor pathway. Thrombosis and Haemostasis. 2016;116(2):379-393.
• Sánchez-Hernández RM, Civeira F, Stef M, Perez-Calahorra S, Almagro F, Plana N et al. Homozygous Familial Hypercholesterolemia in Spain: Prevalence and Phenotype-genotype Relationship. Circulation. Cardiovascular genetics. 2016;9(6):504-510.
Highlights
The scientific activity of the research group during 2016 we wish to emphasize the the continuity of three research projects competitive and multidisciplinary led by the Dr. Ascaso, Dr. Real and Dr. Chaves. The Project led by Dr. Ascaso, entitled “Immunopharmacological modulation of the systemic inflammation associated to metabolic disorders. Search
for new therapeutic targets and synthesis of novel drugs”, studies the role of shaft CCL11/CCR3 in systemic inflammation associated with Familial Hypercholesterolemia and its immune modulation by oral
lipid overload, as well as the study of the role of the axis CXCL16/CXCR6 in Ang-II-induced Endothelial dysfunction in subjects with metabolic síndrome. On the other hand, the main objetive of the project “Study of new infammatory and angiogenic mechanisms associated to severe morbid obesity: Role of CXCR3 axis and the nuclear receptors RORs” led by Dr. Real, is to explore the CXCR3 axis and RORs receptors in patients with severe morbid obesity with or without diabetes undergoing a gastric bypass. And finally, the main objetive of the project led by Dr. Chaves, “Identification of exome sequence variations alterations of methylation and hydroxymethylation associated with the development of type 2 diabetes”, evaluates
the influence of sequence variations and methylation and hydroxymethylation of the coding and splicing regulatory sequences have on the development of T2DM.
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