Page 31 - CIBERDEM2016-ENG

Most relevant scientific articles
• Fernandez-Millan E., Martin M.A., Goya L., Lizarraga-Mollinedo E., Escriva F., Ramos S. et al. glucagon-like peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and nrf2 translocation. Free Radical Biology and Medicine. 2016;95:16-26.
• Martin MÁ, Goya L, Ramos S, Álvarez Escola Carmen. Anti-diabetic actions of cocoa flavanols. Molecular nutrition & food research. 2016.
• Diaz-Castroverde S., Gomez-Hernandez A., Fernandez S., Garcia-Gomez G., Di Scala M., Gonzalez- Aseguinolaza G. et al. Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice. DMM Disease Models and Mechanisms. 2016;9(11):1271-1281.
• Goya L., Martin M.A., Sarria B., Ramos S., Mateos R., Bravo L. Effect of cocoa and its flavonoids on biomarkers of inflammation: Studies of cell culture, animals and humans. Nutrients. 2016;8(4).
• Fernandez-Gomez B., Ramos S., Goya L., Mesa M.D., del Castillo M.D., Martin M.A. Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic InS-1E beta cells. Food Research International. 2016.
Highlights
RESULTS
• The incretin GLP-1 effectively protects ß-cells from oxidative stress by improving their antioxidant capacity through the increased enzymatic activity of glutathione-peroxidase and -reductase via PKA- dependent activation of ERK and nrf2 nuclear translocation.
• The blockage of autophagic activity in the endocrine pancreas seems to be required during postnatal remodeling in order to ensure the correct ß-cell turnover by apoptosis. This blockage might be associated to disappearance of islet IgF-2 expression since sustained IgF-2 stimulation of InS-1E cells inhibits mTORC1 activity and increases autophagy flux.
• Coffee silverskin extract improves glucose-stimulated insulin secretion and protects against streptozotocin-induced damage in pancreatic ß-cells.
FUnDIng
• Molecular and cellular mechanisms involved in T2DM and obesity pathogenesis in rats submitted to maternal undernutrition and refed a high fat diet after weaning. MINECO. BFU 2011-25420. PI: Carmen Álvarez (2012-2016).
• Environmental factors involved in metabolic syndrome development: nutritional restriction and gut microbiota. MINECO Ref. BFU2016-77931-R. IP: Carmen Álvarez Escolá (2016-2019).
MEETIngS
• Fernández-Millán et al. Role of the (macro)autophagy in the postnatal regeneration of endocrine pancreas and its relationship with IGF-2. 52nd EASD Meeting (2016)
• Rodríguez-Rivera et al. Clusterin, a proposed biomarker of food addiction is upregulated in the Nucleus Accumbens of undernourished rats. 46th SfN’s (Neurosciences) Meeting (2016)
• Fernández-Millán et al. Identification of new mechanisms involved in the postnatal regeneration of endocrine pancreas: role of the autophagy in beta-cells and its relationship with IgF-2. XXXIX Congreso de la SEBBM (2016). Invitación
• Rodríguez-Rivera et al. Sobre-expresión de la clusterina en el núcleo accumbens de ratas subnutridas. 25 Congreso Farmadrid (2016)
DEM
research groups 31