Page 61 - CIBERDEM-2015-eng

• Role of atypical catecholaminergic cells in devel- • Involvement of Tyrosine Hydroxilase in the metabol- oping mouse pancreas. ic adaptations to diet and temperature stressors.
Most relevant scientific articles
Research groups
PILAR VALDECANTOS M., PRIETO-HONTORIA P.L., PARDO V., MODOL T., SANTAMARIA B., WEBER M. ET AL. Essential role of Nrf2 in the protective effect of lipoic acid against lipoapop- tosis in hepatocytes. Free Radical Biology and Medicine. 2015;84:263-278.
Biochimica et Biophysica Acta - Molecular Cell Research. 2015;1853(12):3224-3234.
ARROBA A.I., VALVERDE A.M.. Inhibition of protein tyros- ine phosphatase 1B improves IGF-I receptor signaling and protects against inflammation-induced gliosis in the
PARDO V., GONZáLEZ-RODRíGUEZ A., GUIJAS C., BALSINDE J., VALVERDE A.M.. Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation. Journal of Biological Chemistry. 2015;290(18):11663-11677.
SANTAMARIA B., MARQUEZ E., LAY A., CAREW R.M., GONZáLEZ- RODRíGUEZ A., WELSH G.I. ET AL. IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.
Highlights
RESEARCH PROJECTS:
• Inhibition of protein tyrosine phosphatase in the treatment of type 2 diabetes: effects in diabetic complications and cell proliferation (SAF2012- 33283, MINECO, Spain).
• Neuroprotection in retinitis pigmentosa based on the modulation of cell death and inflammation (SAF2013-41059R, MINECO, Spain).
• Study of the mechanisms of insulin resistance: implications in obesity, diabetes and metabolic syndrom. S2010/BMD-2423. Consortium MOIR- CM (Comunidad de Madrid, Spain).
retina. Investigative Ophthalmology and Visual Science. 2015;56(13):8031-8044.
GONZáLEZ-RODRíGUEZ A., SANTAMARIA B., MAS-GUTIéR- REZ J.A., RADA P., FERNáNDEZ-MILLAN E., PARDO V. ET AL. Resveratrol treatment restores peripheral insulin sensitiv- ity in diabetic mice in a sirt1-independent manner. Molec- ular Nutrition and Food Research. 2015;59(8):1431-1442.
• Neurodegeneration as an early event in the Patho- genesis of Diabetic Retinopathy: A multicentric, prospective, phase II-III, double blind randomized controlled trial to assess the efficacy of neuropro- tective drugs administered topically to prevent or arrest Diabetic Retinopathy (EUROCONDOR) FP7- HEALTH-2011-two-stage HEALTH.2011.2.4.3.1 (2012-2016).
• Identification of novel modulators of chronic inflammation in prevalent diseases: unveiling divergent mechanisms of disease. INFLAMES. PIE14/00045, Proyecto Integrado de Excelencia, Convocatoria 2014 de la Acción Estratégica en Salud 2013-16, ISCIII.
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas
Contact: Instituto de Investigaciones Biomédicas Alberto Sols. C/ Arturo Duperier 4. 28029 Madrid Tel.: 91 585 44 97 · E.mail: [email protected] · Website: http://www.iib.uam.es; www.cib.csic.es
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