Page 60 - CIBERDEM-2015-eng

Research groups
Molecular mechanisms of insulin resistance, insulin sensitivity, islet development and diabetic complications Programme: P1
Lead Researcher: Martínez Valverde, Ángela María
Group members
STAFF MEMBERS: García Ruiz, Inmaculada | Murillo Gómez, Cayetana | Pardo Marques, Virginia. ASSOCIATED MEMBERS: Ahmed, Maysha | De Pablo Dávila, Flora | Hernández Sánchez, Catalina |
Santamaría Pérez, Beatriz | Villar Lorenzo, Andrea.
Main lines of research
• Molecular mechanisms associated to the progres- sion of non-alcoholic fatty liver disease (NAFLD):
- Dual role of the protein tyrosine phosphatase 1B (PTP1B) in NAFLD: from intestinal inflammation to hepatic fibrosis.
- Cross-talk between different liver cells (hepato- cytes, Kuffer cells, stellate cells) in the context of NAFLD progression: molecular mechanisms in- volved.
- Differential effects of single and dual agonists of glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) in the treatment of NAFLD at stages of steatohepatitis (NASH).
• Differential therapeutic effects of single and dual agonists of glucagon-like peptide-1 receptor (GLP- 1R) and glucagon receptor (GCGR) in the treat- ment of insulin resistance associated to obesity: effects of these drugs in the brown adipose tissue.
• Effect of low grade chronic inflammation on insu- lin and catecholamine sensitivity in brown adipo- cytes: molecular mechanisms involved.
• Role of insulin receptor substrate 2 (IRS2) in the epithelial-mesenchymal transition (EMT) during pre-fibrotic stages in kidney and liver.
• Role of protein tyrosyne phosphatase 1B (PTP1B) in IGF-I and proinsulin-mediated signalling in the retina: possible benefits of PTP1B inhibition in the impairment of survival of photoreceptor cells.
• Study of the polarization of microglia (M1/M2) in diabetic retinopathy (DR): targeting microglia po- larization as a therapeutic approach at the early stages of DR.
• Physiological role of proinsulin and the conse- quences of inappropriately high levels during car- diogenesis.
60 I Annual report 2015 I CIBERDEM