Page 41 - CIBERDEM-2015-eng

may provide the rational basis for the development of lifestyle changes or drugs that promote IRS2 expres- new and innovative strategies for the detection, treat- sion or function.
ment and prevention of metabolic disorders including
Most relevant scientific articles
Research groups
VINUE áNGELA, ANDRES-BLASCO I., HERRERO-CERVERA A., PIQUERAS L., ANDRES V., BURKS D.J. ET AL. Ink4/Arf locus re- stores glucose tolerance and insulin sensitivity by reducing hepatic steatosis and inflammation in mice with impaired IRS2-dependent signalling. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2015;1852(9):1729-1742.
ANDRES-BLASCO I., HERRERO-CERVERA A., VINUE A., MARTíN- EZ-HERVAS S., PIQUERAS L., SANZ M.J. ET AL. Hepatic
Highlights
PROJECTS FUNDED/ACTIVATED IN 2015:
• BFU2014-58686-P (Luke Noon): “SIL-iver”, Local insulin signaling in liver. 145.200,00€ administered by CIBERDEM.
• Proyecto Paula (Herminia Gonzalez). 50.000€. This grassroots funding effort seeks to strengthen dia- betes research by providing laboratory personnel.
• PI13/00834, ISCIII (Herminia Gonzalez). 89.200€. “Study of Molecular Mechanisms of Diabetes and their role in the Development of Atherosclerosis”.
• Private Contract with biotech Fibrostatin (Debo- rah Burks). 100.000€. Test potential anti-diabetic compound in mouse models.
STUDENTS TRAINED IN 2015:
• Proyecto TFG: María José Arámbul Anthony (NIF: 53788752D) – Universidad Politecnica de Valencia (600 hours) – Result 10/10 (Cum Laude), Defend- ed 17/07/15
• Proyecto TFM: Luis Ferriol Huedo (NIF: 48596149R) – Universidad de Valencia (800 hours) – Result 9,5/10Defended 23/09/15
• FCT: Marta Galvez Viedma – Centre Integrat Pú- blic de Formació Professional Mislata (380 hours)
• Prácticas: Irene Garcés Lázaro, NIF 73412297T –
Universitat de Lleida (120 hours) COLLABORATIONS: We have established a series
of important collaborations with a diverse group of international researches, including:
• Professor Scott Friedman (MSSM, New York, USA)
• Professor Alexander Levitzki (Hebrew University of
Jerusalem, Israel)
lipase deficiency produces glucose intolerance, inflam- mation and hepatic steatosis. Journal of Endocrinology. 2015;227(3):179-191.
TOLOSA L., CARON J., HANNOUN Z., ANTONI M., LóPEZ S., BURKS D. ET AL. Transplantation of hESC-derived hepato- cytes protects mice from liver injury. Stem Cell Research and Therapy. 2015.
• Dr Anne Corlu (Inserm UMR991, Rennes, France) • Dr Ann-Sophie Armand (Inserm UMR 1124, Paris,
France)
• Professor Jerónimo Forteza (CIPF, Valencia, Spain) • María J. Vicent (CIPF, Valencia, Spain)
We have also established collaborations with several small biotech companies:
• Oncovision (CIPF, Valencia, Spain)
• Cellgenix (Ursula Schultz, Freiburg, Germany)
• Fibrostatin (Valencia, Spain)
DISSEMINATION: Our work has been presented seminars as well as at a series of international con- gresses:
• 10/03/15: Inserm U522 “Local insulin signalling: A
role in hepatogenesis and liver cancer?” Rennes,
France.
• 17/07/15: CIPF internal seminar, “The Role of Insu-
lin Substrate Receptor 2 (IRS2) in Hepatocellular Carcinoma (HCC): a local insulin signalling (LIS) view”, Valencia.
• 12/02/15: CIPF internal seminar, “Patterning of lo- cal insulin/IGF1 signalling by insulin receptor sub- strate (IRS) gene expression in vitro and in vivo”.
• 13-17/11/15: 66th Annual Meeting of the Ameri- can-Association-for-the-Study-of-Liver-Diseases (AASLD). San Francisco, (USA).
• 14-18/09/15: 51st Annual Meeting of the Europe- an-Association-for-the-Study-of-Diabetes (EASD), Stockholm, (Sweden).
Institution: Fundación Centro de Investigación Príncipe Felipe · Contact: C/ Eduardo Primo Yúfera 3. 46013 Valencia · Tel.: 96 328 96 80 · E.mail: [email protected] · Web: http://www.cipf.es
CIBERDEM I Annual report 2015 I 41