Page 38 - CIBERDEM-2015-eng

Research groups
Transgenic animal models and gene therapy
approaches for diabetes
Programme: P2
Lead Researcher: Bosch Tubert, Fátima
Group members
STAFF MEMBERS: Casellas Comallonga, Alba.
ASSOCIATED MEMBERS: Barrero Victorio, Jennifer | Carretero Romay, Ana | Elias Puigdoménech, Ivet | Ferré Masferrer, Ma del Tura | Franckhauser, Sylvie | García Martínez, Miguel | Haurigot, Virginia | Jiménez Cenzano, Veronica | León Madrenas, Xavier | Maggioni, Luca | Mallol Domínguez, Cristina | Melgarejo Bermúdez, Verònica | Molas Laplana, María | Morró Larrubia, Meritxell | Moya Martínez, Marta | Muñoz Forero, Sergio Antonio | Nacher García, Victor | Navarro Beltrán, Marcos | Otaegui Goya, Pedro José | Pujol Altarriba, Anna | Ribera Sánchez, Albert | Roca Lecha, Carles | Ruberte Paris, Jesús | Vilà Prats, Laia | Zaguirre Sánchez, Mireia.
Main lines of research
Study of causes and pathophysiological mecha- nisms of diabetes and obesity.
• Study of the role of pancreatic ß cell alterations in the development of diabetes.
• Identification of novel genes in adipose tissue in- volved in the development of diabetes and obesity.
• Identification of novel mechanisms involved in browning of white adipose tissue.
Development of new gene therapy approaches for diabetes
• Gene therapy approaches for the treatment of type 1 diabetes centered on genetic engineering of skel- etal muscle to produce insulin and/or increase glu- cose uptake.
• Gene therapy approaches for type 2 diabetes and obesity centered on genetic engineering of skeletal muscle and/or the liver.
• Study of in vivo pancreas regeneration in diabetic animals:
-Regeneration of endocrine pancreas by IGF-1
-Betasel: in vivo selection of genes to improve beta cell mass
• Development of new approaches for type 2 diabe- tes and obesity centered on genetic engineering of adipose tissue.
38 I Annual report 2015 I CIBERDEM