Page 36 - CIBERDEM-2015-eng

Research groups
Brain glucose sensor, satiety control, insulin
resistance and type 2 diabetes
Programme: P1 / P3
Lead Researcher: Blázquez Fernández, Enrique
Group members
STAFF MEMBERS: Gutiérrez Nogues, Ángel | Hurtado Carneiro, Verónica.
ASSOCIATED MEMBERS: Álvarez García, Elvira | Navas Hernández, María de los Ángeles | Roncero Rincón,
Isabel | Ruiz Albusac, Juan Miguel | Sanz Miguel, Carmen | Velázquez Sánchez, Esther.
Main lines of research
• Modifications of cerebral glucose metabolism in pathophysiological states related to feeding be- haviour.
• The effects of GLP-1 and GLP-2 on the expression and activity of hypothalamic metabolic sensors and characterization of the neuroprotective role of these peptides.
• The effect of GLP-2 on the proliferation and apop- tosis of cultured rat astrocytes.
• Signalling and the biological effects of GLP-1 on mesenchymal stem cells of human bone marrow and mouse embryonic stem cells - its effect on cell differentiation.
• Molecular diagnosis of monogenic diabetes (MODY) and the functional characterization of MODY mutations.
36 I Annual report 2015 I CIBERDEM