Page 31 - CIBERDEM-2015-eng

Research groups
Most relevant scientific articles
RUBIO J.M., RODRíGUEZ J.P., GIL-DE-GóMEZ L., GUIJAS C., BAL- BOA M.A., BALSINDE J.. Group V secreted phospholipase A2 is upregulated by IL-4 in human macrophages and medi- ates phagocytosis via hydrolysis of ethanolamine phos- pholipids. Journal of Immunology. 2015;194(7):3327-3339.
Highlights
GRANTS ACTIVE IN 2015
• “Role of lipin-2 in regulating autoinflammatory diseases”. Autonomous Government of Casdtile and Leon, Heath Department (BIO/VA22/15).
• “Lipid Pathways Regulating the Inflammasome: Role of Omega-3 Fatty Acids and Lipin-2”. Minis- try of Economy and Competitiveness (SAF2013- 48201-R).
RESEARCH CONTRACTS WITH PRIVATE COM- PANIES
• FIV Recoletos, “Study of the role of the eicosa- noids in implantation and in gestational diabetes”.
MOST RELEVANT RESULTS
• Discovery of new lipids synthesized by inflamma- tory cells with possible roles in regulating fat stor- age in the form of lipid droplets.
• Demonstration that macrophages utilize different lipid signaling pathways depending on their state of polarized activation (M1 vs M2).
• Identification of a critical role for cytosolic group IVA phospholipase A2 in early adipocyte differen- tiation and diet-induced obesity.
PARDO V., GONZáLEZ-RODRíGUEZ A., GUIJAS C., BALSINDE J., VALVERDE A.M.. Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation. Journal of Biological Chemistry. 2015;290(18):11663-11677.
TRAINING
• MSc thesis: “Regulation of lipid droplet formation in human cells”, Rafael Sánchez Martínez, Univer- sity of Valladolid.
• MSc thesis: “Activation of monocytes by oxidized derivatives of arachidonic acid”. Miguel Angel Bermúdez Arias, University of Valladolid.
• Grade in Chemistry Thesis: “Identification of po- sitional isomers of palmitoleic acid in biological samples”, Ramón Francia Yanguas, University of Valladolid.
OTHER ACTIVITIES
• The group PI, Prof. J. Balsinde, was a keynote speaker in the 6th International Conference on Phospholipase A2: from Bench to Translational Medicine, held in Tokyo, Japan (Feb. 2015). He was appointed as Co-director of Research Pro- grams by the Argentine National Research Coun- cil (CONICET). Finally, he continues to serve in the Editorial Boards of Journal of Lipid Research and Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.
Institution: Agencia Estatal Consejo Superior de Investigaciones Científicas
Contact: Instituto de Biologia y Genética Molecular. C/ Sanz y Fores S/N. 47003 Valladolid Tel.: 98 342 30 62 · E.mail: [email protected] · Website: http://www.balsinde.org
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