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Most relevant scientific articles
• Salord N., Fortuna A.M., Monasterio C., Gasa M., Pérez A., Bonsignore M.R. et al. A randomized controlled trial of continuous positive airway pressure on glucose tolerance in obese patients with obstructive sleep apnea. Sleep. 2016;39(1):35-41.
• Julve J., Martín-Campos J.M., Escolà-Gil J.C., Blanco-Vaca F. Chylomicrons: Advances in biology, pathology, laboratory testing, and therapeutics. Clinica Chimica Acta. 2016;455:134-148.
• Fernández-Suárez M.E., Escolà-Gil J.C., Pastor O., Davalos A., Blanco-Vaca F., Lasuncion M.A. et al. Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport. Scientific Reports. 2016;6.
• Cedo L., García-León A., Baila-Rueda L., Santos D., Grijalva V., Martínez-Cignoni M.R. et al. ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer. Scientific Reports. 2016;6.
• Amigó N, Mallol R, Heras M, Martínez-Hervás S, Blanco-Vaca F, Escolà-Gil JC et al. Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: “Herniated” HDL, a common feature in diabetes. Scientific reports. 2016;6:19249.
Highlights
PROJECTS
• Coordinated project with other CIBERDEM groups funded by the Fundació La Marató de TV3 with the title: Preventing Premature Coronary Heart Disease in Catalonia by Expanding Familial Hypercholesterolemia Diagnosis.
• Coordinated project with other CIBERDEM groups funded by the Fundació La Marató de TV3 with the title Lipotoxicity and microvascular disease: Contribution to myocardial damage in clinical and experimental models of diabetes.
• Project funded by the Spanish Society of Arteriosclerosis with the title “Analysis of the effect of nicotinamide administration on the body weight and quantitative and qualitative properties of lipoproteins and its relationship with the development of atherosclerosis in experimental models.”
RESULTS
• ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumor growth in a mouse model of inherited breast cancer and human breast adenocarcinoma MCF-7 cells.
• Continuous positive airway pressure treatment improves glucose tolerance in morbidly obese patients with severe obstructive sleep apnea.
• Obesity impairs the main cardioprotective HDL function, the macrophage-to-feces reverse cholesterol transport in obese db/db mice, by downregulating hepatic ABCG5/G8 transporters. A favorable upregulation of the hepatic levels of ABCG5/G8 is found in morbid obese patients undergoing Roux-en-Y gastric bypass surgery.
• The administration of nicotinamide (derived from vitamin B3) reduces weight gain concomitantly with lower adiposity and worse dietary caloric efficiency in a mouse model of obesity and insulin resistance.
DEM
research groups 39