Page 73 - CIBERDEM-2015-eng

Research groups
Most relevant scientific articles
AMOR A.J., MASANA L., SORIGUER F., GODAY A., CALLE-PAS- CUAL A., GAZTAMBIDE S. ET AL. Estimating cardiovascular risk in spain by the European guidelines on cardiovascular disease prevention in clinical practice. Revista Espanola de Cardiologia. 2015;68(5):417-425.
Highlights
PASTOR P, MORENO F, CLARIMóN J, RUIZ A, COMBARROS O, CALERO M ET AL. MAPT H1 Haplotype is Associated with Late-Onset Alzheimer’s Disease Risk in APOEe4 Noncarri- ers: Results from the Dementia Genetics Spanish Consorti- um.Journal of Alzheimer’s disease: JAD. 2015;49(2):343-52.
Three different studies were conducted:
A. To describe cause-specific morbidity and mortal- ity risk factors in a previously well characterized population. (Segovia Study) after 10 years fol- low-up.
• Design: Prospective population-based (10 years) follow-up survey of 900 subjects previously re- cruited in 2001-2003 in the province of Sego- via (Autonomous Community of Castilla y León, Spain). 719 subjects from 12 out of 14 Primary Care centres included in the cross-sectional sur- vey were invited to participate.The health status was checked through medical records. End-point of the study: diagnosis of cardiovascular disease (CVD), neoplasms and/or other major diseases or death.
• Results: Total mortality: 7,4%. Causes of death: cancer (49%) cardiovascular events (21,6%); 16,1 % of subjects developed cardiovascular event, with stroke as the leading cause (24,8 %). iii) Con- clusions: Neoplasia is the main cause of death in middle aged and elderly subjects considered together, followed by CVD. Stroke was the most frequent cardiovascular event.
B. Analysis of specific polymorphisms (SNPs: rs7789066 / rs11977021 / rs4730153) visfatin gene and its influence on cardiovascular risk in obesity and impaired glucose tolerance, as well as its relation to insulin sensitivity.
Conclusion: For the first time we showed that genotype adenine-adenine (AA) of the SNP rs4730153 appears to be protects from cardio- vascular disease (Framingham and SCORE crite- ria) in subjects with / without obesity.
C. Currently developing Project: to investigate the potential association of circulating levels of Reti- nol Binding Protein 4 (RBP4) with insulin sensi- tivity tissue estimated by different indexes (HO- MA-IR, Stumvoll, Matsuda).
Institution: Servicio Madrileño de Salud · Contact: Hospital Clínico San Carlos. Avda. Complutense S/N 28040 Madrid · Tel.: 91 330 33 88 · E.mail: [email protected]
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