Page 27 - CIBERDEM-2015-eng

Research groups
Most relevant scientific articles
GONZáLEZ-RODRíGUEZ A., SANTAMARIA B., MAS-GUTIéR- REZ J.A., RADA P., FERNáNDEZ-MILLAN E., PARDO V. ET AL. Resveratrol treatment restores peripheral insulin sensitiv- ity in diabetic mice in a sirt1-independent manner. Molec- ular Nutrition and Food Research. 2015;59(8):1431-1442.
FERNáNDEZ-MILLáN E, CORDERO-HERRERA I, RAMOS S, ES- CRIVá F, áLVAREZ C, GOYA L ET AL. Cocoa-rich diet atten- uates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta
LIZARRAGA-MOLLINEDO E., FERNáNDEZ-MILLAN E., FRUTOS M.G.-S., DE TORO-MARTíN J., FERNáNDEZ-AGULLO T., ROS M. ET AL. Early and long-term undernutrition in female rats exacerbates the metabolic risk associated with nu- tritional rehabilitation. Journal of Biological Chemistry. 2015;290(31):19353-19366.
CORDERO-HERRERA I., MARTíN M., ESCRIVA F., ALVAREZ C., GOYA L., RAMOS S.. Cocoa-rich diet ameliorates hepatic insulin resistance by modulating insulin signaling and glu-
cell apoptosis.Molecular nutrition & food research. 2015;.
CORDERO-HERRERA I, MARTíN MA, GOYA L, RAMOS S. Cocoa flavonoids protect hepatic cells against high-glucose-in- duced oxidative stress: Relevance of MAPKs.Molecular nutrition & food research. 2015;.
Highlights
Undernourished rats transferred to high-lipid diets did not develop obesity but showed increased meta- bolic risks including worsening of insulin resistance, dyslipidemia and ectopic lipids.
Our findings provide the first in vivo evidence that a cocoa flavonoid-rich diet may delay the progression of type 2 diabetes by preventing, both in pancreas and liver, oxidative stress and cell apoptosis which improves glucose metabolism and avoids the loss of functional beta-cell mass.
FUNDING:
Molecular and cellular mechanisms involved in T2DM and obesity pathogenesis in rats submitted to maternal undernutrition and refed a high fat diet after weaning. MINECO. BFU 2011-25420. PI: Car- men Álvarez (2012-2015).
Study of the mechanisms of insulin resistance: impli- cation in obesity, diabetes and metabolic syndrome (MOIR). CAM P2010/BMD-2423 I+D Programs of Bi- omedicine/2010. Coordinator: Manuel Ros (URJC). Enmeper Group-PI: Fernando Escrivá (2012-2015).
cose homeostasis in Zucker diabetic fatty rats. Journal of Nutritional Biochemistry. 2015;26(7):704-712.
CONGRESSES:
Fernández-Millán et al. El retraso en el crecimiento in- trauterino compromete la movilización hepática del glucógeno tras el nacimiento asociada a un defecto del flujo autofágico en ratas Wistar. XXVI SED Con- gress. (Spain), 2015. Oral presentation.
De Toro-Martín et al. Maternal undernutrition induces defective autophagy and glycogen accumulation in the liver of newborn Wistar rats. 75th ADA Congress. (USA), 2015. Póster
LizárragaMollinedo et al. Alteraciones del tejido ad- iposo inducidas por la realimentación con dieta hi- perlipídica en ratas con un antecedente previo de re- stricción calórica severa. XXXVIII SEBBM Congress. (Spain), 2015. Oral presentation.
Díaz-Castroverde et al. Gene therapy with insulin re- ceptor isoform A as an approach for the treatment of type 2 diabetes. XXXVIII SEBBM Congress. (Spain) 7-10 Septiembre, 2015. Oral presentation.
Cordero-Herrera et al. Cocoa-rich diet improves hepat- ic lipid metabolism in Zucker diabetic fatty rats. 2nd ISCHOM Congress. (Spain), 2015. Oral presentation.
AWARDS:
Margarita Lorenzo Scientific Award (Lilly Fundation) (Congreso SEBBM 2015).
Juan Abelló Scientific Award (RANF 2015).
Institution: Universidad Complutense de Madrid · Contact: Facultad de Farmacia.
Ciudad Universitaria, S/N. 28040 Madrid · Tel.: (+34) 91 394 18 57 · E.mail: [email protected] Web: http://www.ucm.es/biomol2/endocrinologia-y-metabolismo-perinatal
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