Page 73 - CIBERDEM2016-ENG

Most relevant scientific articles
• Garcia-Arévalo M., Alonso-Magdalena P., Servitja J.-M., Boronat-Belda T., Merino B., Villar-Pazos S. et al. Maternal exposure to bisphenol-A during pregnancy increases pancreatic β-cell growth during early life in male mice offspring. Endocrinology. 2016;157(11):4158-4171.
• Lind L., Mónica Lind P., Lejonklou M.H., Dunder L., Bergman A., Guerrero-Bosagna C. et al. Uppsala consensus statement on environmental contaminants and the global obesity epidemic. Environmental Health Perspectives. 2016;124(5):A81-A83.
• Vettorazzi J.F., Ribeiro R.A., Borck P.C., Branco R.C.S., Soriano S., Merino B. et al. The bile acid TUDCA increases glucose-induced insulin secretion via the cAMP/PKA pathway in pancreatic beta cells. Metabolism: Clinical and Experimental. 2016;65(3):54-63.
• Tuduri E., López M., Dieguez C., Nadal A., Nogueiras R. glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets. Trends in Endocrinology and Metabolism. 2016;27(5):304-318.
• Mellado-Gil J.M., Jiménez-Moreno C.M., Martín-Montalvo A., Álvarez-Mercado A.I., Fuente-Martín E., Cobo-Vuilleumier N. et al. PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus. Diabetologia. 2016;:1-11.
Highlights
During 2016, we have shown in mice that maternal exposure to the endocrine disruptor bisphenol-A during gestation increases beta cell mass in offspring from the first day of birth. This is associated to alterations
in the expression of genes related to cell growth, favoring an increase in the proliferation and a decrease
of apoptosis of the pancreatic beta cell in offspring. We have also described that the bile acid TUDCA is able to regulate insulin secretion from beta cells through the protein kinase A pathway. During this year we have been involved in the development of a consensus document on the contribution of environmental contaminants to the epidemics of obesity.
At the end of 2016, we began to study the role of pancreatic alpha cells and glucagon secretion in glucose homeostasis during aging, a national Plan project granted this year.
The researchers of the group have been invited to the congresses: XXVII national Congress of the Spanish Society of Diabetes, Bilbao, April 2016; Environmental Endocrine Disruptors, gordon Research Conference, Sunday River, Maine, June 2016; XIV International Congress of Toxicology Merida-Mexico, October 2016.
DEM
research groups 73