Page 22 - CIBERDEM-2015-eng

Platforms
Biorepository of Diabetes
and Metabolic Diseases CIBERDEM-IDIBAPS
This is a mixed CIBER-IDIBAPS platform forming part of the IDIBAPS Biobank with the aim of provid- ing the scientific community with properly-charac- terised and standardised samples of the main met- abolic diseases. The CIBERDEM groups providing samples to the Biorepository are:
• Hospital Clinic Barcelona
• Hospital Joan XXIII de Tarragona
• Hospital San Joan de Reus
• Hospital de Cruces de Barakaldo
SOURCES OF THE SAMPLES
• Hospital Clínico de Madrid
• Hospital Clínico de Valencia
• Hospital Carlos Haya de Málaga
• Hospital Santa Creu y San Pau de Barcelona
The Biorepository currently has a total number of 12399 samples of whole blood, plasma, serum, DNA and lymphocytes of people with the following char- acteristics:
Diabetes type 1
Diabetes type 2
Obesity
Morbid Obesity
Dyslipaemia
Gestational Diabetes
Monogenic Diabetes
PREDAPS study: population with prediabetes and control population [email protected] study: general population
The samples are deposited at the IDIBAPS Biobank. The Diabetes study has several copies of samples. One of these is deposited at the Hospital de Cruces and at the Hospital Carlos Haya (50% at each of these) as a backup copy.
In 2015 samples of donors belonging to the PREDAPS and follow-up donations were received.
In 2015 a total number of 10646 different aliquots were given, mainly for projects in the [email protected] study. The projects involved are as follows:
• Circulating exosomal miRNAs as potential bio- markers and mediators of tissue cross-talk in dia- betes.
• Association of Fibroblast Growth Factor 21 with the ambient temperature in the general population of Spain. [email protected] study (proyecto [email protected]).
• Genetic and environmental factors of insulin resist- ance syndrome and its long-term complications in immigrant Mediterranean populations (proyecto [email protected]).
• Understanding the pathophysiological signifi- cance of succinate/SUCNR1 axis in obesity and type 2 diabetes: a translational approach (proyec- to [email protected]).
• Profile of membrane fatty acids and glucose reg- ulation profile: [email protected] cohort ([email protected] pro- ject).
In the framework of the European MEDIGENE pro- ject, the Biorepository also contains 75 samples of amplified DNA obtained from the molars found in the ancient Roman city of Tarraco.
22 I Annual report 2015 I CIBERDEM