Page 18 - CIBERDEM-2015-eng

Scientific Programmes
PROGRAMA 3. Cellular and molecular mechanisms involved in the development and progression of type 2 diabetes and identification of new therapeutic targets
1. Determinants of resistance to insulin: molecular mechanisms involved.
We have shown that Osteoprotegerin is associated with bone markers and with bone mineral density in the lumbar spine after bariatric surgery. This can en- able explaining the development of metabolic bone disease after bariatric surgery (Balsa et al., J Bone Miner Metab. 2015).
We have reported that the hepatic levels of phos- phatase protein PPP2R5C are increased in type 2 di- abetic patients and this is correlated with the degree of obesity and resistance to insulin in these patients. The PPP2R5C protein represents a relevant factor in the modulation of hepatic energy metabolism (Cheng et al., PLoS Genet. 2015).
2. Inflammation as a pathogenic process in diabetes mellitus: The role of adipose tissue and interaction with other tissues or organs.
An alteration in the glycogen metabolism in the ad- ipose tissue represents a potential characteristic of metabolic stress related with inflammation in hu- man obesity (Ceperuelo-Mallafré et al, Mol. Metab. 2015).
3. Identification of molecular mechanisms and new therapeutic targets for development of personalised early interventions in diabetes mellitus.
We have proved that the accumulation of hepatic gly- cogen causes a reduction in intake which promotes protection against the harmful effect in a fat-rich diet. Hepatic glycogen content can thus be consid- ered as being a potential target for pharmacological manipulation in diabetes and obesity (López-Solda- do et al., Diabetes 2015).
4. Identification of risk progression
biomarkers in diabetes.
We have identified alterations in the levels of circu- lating miRNAs in maternal obesity and our results suggest a possible role of these miRNAs as markers for prenatal and postnatal growth (Carreras-Badosa et al., J.Clin.Endocrinol.Metab. 2015).
We have described an early increase in the circulat- ing levels of FGF19 and FGF21 during infancy, which must play a relevant metabolic role during this condi- tion (Sánchez-Infantes et al., Int.J. Obes. 2015).
The “Liposcale” test has been developed as a repro- ducible and effective method of detecting the lipopro- tein profile based on the use of NMR spectroscopy (Mallol et al., J. Lipid Res. 2015).
The serum levels of sulfoxide of methionine are an indicator of the degree of oxidation of the residue of methionine 148 of apolipoproteín A1 in girls with hy- perinsulinaemia through androgen excess (Samino et al., Sci Rep 2015). The oxidation of this methionine residue of apo-A1 leads to an altered maturing of HDL lipoproteins.
18 I Annual report 2015 I CIBERDEM